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Colonoscopy screening prevents approximately two thirds of the deaths due to colorectal cancers on the left side of the colon, and is not associated with a significant reduction in deaths from right-sided disease.

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Amitiza is approved by the FDA for the treatment of IBS-C, as well as for (CIC).

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Prospective Randomized Single-blind Comparison of Three methods of Bowel Preparation for Outpatient Flexible Sigmoidoscopy”, Surg Endosc (2007) 21: 945-949 (Abstract published in Gastrointest Endosc 2004; (59(5): 127) reported a study concerning the performance of out-patient flexible sigmoidoscopy prospectively randomized to 3 groups: group 1: one Fleet enema 2 hours pre-procedure; group 2: two Fleet enemas, one on the evening prior to sigmoidoscopy and one 2 hours preprocedure; group 3: lactulose 30 ml orally 48 and 24 hours prior to sigmoidoscopy, plus a single Fleet enema 2 hours pre-procedure.

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Supplementation and maintenance of vitamin B 12 and fat-soluble vitamins, with correction of calcium and magnesium deficiencies, are key components of treatment.

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The method of claim 1, wherein the patient has a history of constipation or is chronically being administered a lot of laxatives, further comprising instructing the patient to ingest at least two additional doses of 20 g (each dose) of lactulose.

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For trials with a factorial design, we based main results on 2-way analyses, that is, all trial participants receiving vitamin E were compared with all participants not receiving it.

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