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In the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) study, which involved patients who had symptomatic heart failure and had been hospitalized in the previous 6 months, candesartan, when added to existing therapy with any ACE inhibitor used at variable doses (with less than half the patients receiving full doses), was superior to placebo in reducing death or hospitalization for heart failure.

The angiotensin II receptor blocker, Telmisartan, may increase the adverse effects of Trandolapril.

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