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Can you take more than one prilosec a day? Can I take Prilosec OTC more than once a day ? No. As part of a course of therapy, take only one pill a day to treat frequent heartburn for 24 hours.* Take one pill a day with a glass of water before eating in the morning for 14 days. You may repeat this 14- day treatment every four months, or as directed by your doctor.
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