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In addition, it is a universal fact that the prevalence of UTI is more among women when compared to men due to their reproductive physiology and pregnancy enhances the occurrence of the infection.

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Previous attempts have been made, to administer nitrofurantoin in a slow release or sustained release form in order to minimize these undesirable side-effects.

Generally the commencement of the treatment process starts after the diagnosis of the infection but these initial attempts of treating the disease can lead to problematic consequences as the treatment has to be made after the confirmation of the etiological agent.

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Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

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Calculi may travel down the urinary tract with or without causing damage and may lodge anywhere along the tract or may stay within the kidney.

In bacterial persistence, the same bacteria may be cultured in the urine 2 weeks after initiating sensitivity-adjusted therapy.

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The patient's urine and blood yielded pure cultures of Lactobacillus gasseri, and following treatment with amoxicillin, the patient recovered fully ().

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At interview it was clear that seven of the interviewees had in fact received antibiotic medication.

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Doctors often turn to nitrofurantoin to treat these and other urinary tract infections (UTIs), but concerns have been raised about the ability of the drug to reach the urinary tract and target bacteria that causes bladder infections, especially in those with poor kidney function.

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