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Besides the conditions found in the general population, several conditions occur that are specific to sickle cell disease.

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Efficacy and safety of deferasirox compared with deferoxamine in sickle cell disease: Two-year results including pharmacokinetics and concomitant hydroxyurea.

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In recent years, researchers have reported some success with “half-matched” marrow transplants (haploidentical transplant is the medical term), which uses a donor who shares only 50% of the recipient's genes.

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We compared Visual Analog Scale (VAS) and Numeric Rating Scale (NRS) pain severity ratings in children with sickle cell disease (SCD) to identify the relationship and agreement between pain scale ratings.

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Analysis of daily pain and frequency of pain episodes show that these subjects were severely affected by sickle cell disease at study entry (Fig.

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The latter finding also suggests that in many high risk patients cytoreductive therapy is not adequately aggressive, as demonstrated by the high levels of various hematologic parameters in patients receiving chemotherapy.

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Backonja M, Beydoun A, Edwards KR, Schwartz SL, Fonsecs V, Hes M, LaMoreaux L, Garofalo E, the Gabapentin Diabetic Neuropathy Study Group: Gabapentin for the Symptomatic treatment of painful Neuropathy in patients with Diabetes Mellitus.

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Because of their abnormal shape, the cells periodically clump inside blood vessels, blocking circulation, which can lead to severe anemia, drive up infection and stroke risk and cause episodes of extreme pain.

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This causes a loss of calcium from the bones and an increased level of calcium in the blood.

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Whilst the majority of patients respond well to hydroxyurea, there is a subgroup that appears not to respond.

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An antineoplastic drug, CH 4N 2O 2, that suppresses the production of blood cell precursors in the bone marrow and is used in the treatment of certain leukemias, carcinomas, and sickle cell anemia.

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Women with sickle cell disease (SCD) may have additional considerations that need to be taken into account when assessing the safety of contraceptive methods.

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Patient-controlled analgesia with self-administered bolus morphine and low-dose continuous intravenous infusion is effective and well accepted by patients.

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Hydroxyurea-treated mice showed no improvement in the severe, multi-organ damage, compared to control mice ( and Online Supplementary Table S2).

For example, aspirin and other NSAIDs cause a shift in leukotriene production, which triggers the release of histamine and other mast-cell mediators.

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