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These effects may be of particular importance in diabetic hypertensive patients, who have an impaired fibrinolytic activity, which may contribute to the increased risk of atherosclerosis and its clinical complications.

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If patients with OSD and hypertension should fail to tolerate continuous positive airways pressure (CPAP) therapy, then it seems plausible that aldactone might be useful for lowering their blood pressure: however, this proposition has not yet been tested in clinical trials.

The clinical information represents the expertise and practical knowledge of top physicians and pharmacists from leading academic medical centers in the United States and worldwide.

These data in aggregate suggest that usual patterns of dosing once daily antihypertensive agents may not optimally lower BP and therefore provide maximum protection against cardiovascular disease (CVD).

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However, pathological activation of the RAAS results in excessive vasoconstriction, abnormal muscular (vascular and cardiac) hypertrophy and fibrosis.

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Whether increased levels of bradykinin, a potent vasodepressor peptide, play a role in the therapeutic effects of perindopril remains to be elucidated.

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