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On a body surface area basis, these study doses are 15 and 62 times, respectively, MRHD.

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In addition, stimulation of the alpha-adrenergic receptors, which leads to increased peripheral vascular tone, increases the myocardial workload, which can further decrease cardiac output.

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The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient.

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The bisoprolol-first strategy tended to be more favorable in terms of survival; with bisoprolol-first treatment, fewer patients died, deaths occurred later, and the HR for mortality was 28% lower at the end of the monotherapy phase and 31% lower at 1 year, as compared with the enalapril-first strategy.

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Relation of ADRB1, CYP2D6, and UGT1A1 polymorphisms with dose of, and response to, carvedilol or metoprolol therapy in patients with chronic heart failure analyses were performed to compare the genotype to the metoprolol or carvedilol response status and dose.

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