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Inadequate response for prospective treatment was defined as less than 50% improvement on the 17-item version of the Hamilton Depression Rating Scale (HAMD17), minimal HAMD17 score of 14, and a Clinical Global Impressions Improvement rating of no better than minimal improvement.

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The efficacy and safety of lower doses of aripiprazole for the treatment of patients with acute exacerbation of schizophrenia.

Aripiprazole as an augmentor of selective serotonin reuptake inhibitors in depression and anxiety disorder patients.

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Substrates of CYP isoenzymes 1A2, 2C9, 2C19, 2D6, and 3A4: Pharmacokinetic interaction unlikely.

Differential effects of risperidone, olanzapine, clozapine, and conventional antipsychotics on type 2 diabetes: findings from a large health plan database.

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The efficacy of aripiprazole for the treatment of agitation was established in 3 short-term (24-hour), placebo-controlled trials in agitated inpatients with schizophrenia or bipolar I disorder (manic or mixed episodes, with or without psychotic features).

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Similarly, for treatment of children and adolescents with schizophrenia, atypical and typical antipsychotics appear to be equally effective, but atypical antipsychotics, particularly clozapine and olanzapine, carry a higher risk for metabolic side effects.

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Antidiabetic Agents: Hyperglycemia-Associated Agents may diminish the therapeutic effect of Antidiabetic Agents.

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Based on studies, CYP3A4 and CYP2D6 enzymes are responsible for dehydrogenation and hydroxylation of aripiprazole, and N-dealkylation is catalyzed by CYP3A4.

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Akathisia, a common adverse effect of aripiprazole, may masquerade as treatment-emergent worsening of psychotic symptoms.

The mean time to peak plasma concentration is 3 hours following multiple-dose administration of aripiprazole 10 or 15 mg and the absolute oral bioavailability of the drug is 87%.

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Table 4 shows the proportion of ABILIFY MAINTENA-treated patients with normal and borderline fasting glucose at baseline and their changes in fasting glucose measurements.

Hyperglycemia, in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death, has been reported in patients treated with atypical antipsychotics.

The “good transdermal absorbability” in the present invention means that the transdermal absorption preparation of the present invention is superior in the transdermal absorbability (skin permeability) to transdermal absorption preparations containing aripiprazole in a free form and without coexistence of an organic acid.

To meet quality and standardization objectives, a design solution must be based on an overview of the entire process from delivery of raw materials to the manufacturing site to delivery of product ingredients to the manufacturing line.

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